Solutions · FDA Correspondence

Additional Information requests,
decoded and answered.

An FDA AI request is the highest-anxiety moment in the submission process. Complizen reads the letter, structures your response plan, assigns every outstanding item, and drafts replies with citations — so you can respond confidently, completely, and on time.

Additional Information Request — K24-001234
From: CDRH · Received: March 14, 2025 · Response due: April 14, 2025
Item 1 of 4
Please provide bench testing data demonstrating flex cycle fatigue performance per ASTM F2182 or equivalent standard. The predicate K211045 provided 500-cycle data; your submission references only 250 cycles.
Item 2 of 4
The biocompatibility rationale for the ceramic tip material is insufficient. Please provide either ISO 10993-1 testing or a comparative analysis to a previously cleared material with equivalent contact classification.
Complizen response plan · Item 1
Supplement bench testing to 500 cycles per ASTM F2182-19. Draft response citing K211045 test protocol as precedent. Reference Section 14.2 of original submission. Estimated 2 weeks for testing completion.
Every type of FDA correspondence, handled

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Additional Information (AI)

FDA AI requests — the clock is ticking

30-day response window. Multiple technical items. Complizen reads the letter, assigns each item, drafts response language, and tracks outstanding tasks until your submission is complete.

Refuse to Accept (RTA)

RTA issues — before or after submission

If your submission gets RTAd, Complizen reads the RTA checklist, identifies every deficiency, and generates a correction plan with the exact changes needed to pass RTA on resubmission.

Deficiency Letters

Deficiency letters from CDRH reviewers

Section-specific feedback from your reviewer. Complizen parses each deficiency, drafts a point-by-point response with citations, and flags which sections of your eSTAR need to be updated.

Q-Sub Feedback

Incorporating Pre-Sub feedback

After your Q-Sub meeting, upload FDA's written response. Complizen updates your submission plan, testing strategy, and open questions — so you enter the formal review cycle with FDA already aligned.

How it works

From letter received to response submitted.

01

Upload the FDA letter

Paste or upload the correspondence. Complizen reads and parses every item.

02

Review the structured response plan

Each item gets an action plan, suggested sources, and a draft response paragraph.

03

Refine in Drafting Studio

Edit the response language, add test data, and finalize citations in the editor.

04

Export and submit

Your complete response package, formatted for the FDA portal. Or send for expert review first.

“When an AI request lands on a Friday afternoon, having Complizen draft the response plan over the weekend changes everything. What used to be a 30-day scramble is now days, not weeks.”
Leah Gustke
Leah Gustke
RA/QA Specialist, Exodus New Ventures
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